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Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) amongst South Asians and Caucasians: is there a differe Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1). Journal of Investigative Dermatology; June 2003, vol 120, no 6, pp 905-914. Wijeyaratne, Chandrika N, Adam H Balen, Julian H Barth, Paul E Belchetz. Gynecological Endocrinology; Feb 1, 2003, vol 17, no 1, pp 51-56. It damages the collagen and elastin fibers and makes the skin vulnerable to early wrinkles and fine lines.