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These observations served as a reminder that the seemingly straightforward implementation of GC‐MS analysis can lead to challenges during routine analysis. The comparative result for the analysis of modafinil Online, adrafinil and modafinilic acid under EI-GC-MS and ESI-LC-MS/MS are tabulated in Table 3. The LOD for modafinil and adrafinil was found to be 250 ng/ml on GC-MS and 100 ng/ml on LC-MS/MS.
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