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SUNDAY, July 29 (HealthDay News) -- New gene mutations associated with the event of melanoma have been identified by scientists who performed what is believed to be the largest DNA-sequencing examine of the deadly disease to this point. Melanoma accounts for the overwhelming majority of skin most cancers deaths. The main cause of melanoma is extreme exposure to ultraviolet (UV) radiation from the sun. The Yale Cancer Center team used DNA-sequencing technologies to investigate 147 melanomas originating on each sun-exposed and solar-shielded sites on patients' our bodies. They found a large number of UV-induced mutations in solar-exposed melanomas, however most of those are "passenger" mutations that do not have a useful role in melanoma. Michael Krauthammer, an affiliate professor of pathology, mentioned in a Yale information launch. The researchers pinpointed a mutation within the RAC1 gene that speeds development and movement in normal skin pigment cells, which are the place melanoma begins. The mutation seemingly happens at an early stage of melanoma development and promotes cancer cell development and unfold to different sites within the body, they stated. The RAC1 mutation was found in about 9 % of melanomas from sun-uncovered skin. It's the third-most frequent mutation after previously recognized BRAF and NRAS mutations. Because the RAC1 mutation is so common, it can be worthwhile to develop remedies that concentrate on it, the researchers added. They also recognized mutations that disable proteins that suppress tumors. The study was printed on-line July 29 in the journal Nature Genetics. In the United States, about 76,000 new circumstances of melanoma will probably be diagnosed this 12 months and about 9,000 folks will die of the illness, in accordance with the American Cancer Society.
