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What are the side effects of estradiol? Side effects associated with use of Estradiol, include the following: Abdominal cramping. Anxiety. Bloating. Breakthrough bleeding. Breast enlargement. Breast tenderness/pain/swelling. Freckles or darkening of facial skin (melasma) Changes in menstrual periods.
What happens when you take estrogen pills? Blood clots: Estrogen increases your risk of blood clots, which can cause stroke, heart attack, and even death. Cancer: Estrogen may increase your risk of certain cancers, specifically breast cancer. Dense breast tissue: Women who take estrogen may develop dense breast tissue.
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