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How long does Medrol take to start working? After taking a single dose of Medrol Dosepak it should be out of your system after 8 days (5.5 x 36 hours = 198 hours or just over 8 days). Medrol Dosepak (methylprednisolone) has a medium half life range of 18 to 36 hours - meaning it takes the body 18 to 36 hours to clear 50% of the drug from your plasma.
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