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Is losartan long acting? Losartan Potassium. Losartan potassium (Cozaar, Merck) was the first orally bioavailable, long - acting, nonpeptide AT-II type 1-receptor antagonist to be used in humans. It has been extensively studied in both animals and human volunteers. Losartan has a half-life of 1.5-2.5 hours (Table 1).
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