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Is dexamethasone more potent than prednisone? Oral prednisone and dexamethasone are the currently recommended systemic steroids for moderate to severe asthma exacerbations. Dexamethasone is a long-acting glucocorticoid with a half-life of 36 to 72 hours, and is 6 times more potent than prednisone. Prednisone is shorter acting, with a half-life of 18 to 36 hours.
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