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Так, например, толерантность к барбитуратам, мепробамату, хлорпромазину и диазепаму обусловлена их способностью стимулировать собственный метаболизм цитох-ромами Р-450. Нарушенный метаболизм пропорционален выраженности печеночно-клеточной недостаточности и наибольший — при циррозе печени. Как тренировать силу удара? 3 — метаболизм ЛС является механизмом образования токсических метаболитов — биоактивации (парацетамол). Как правило, они представляют собой молекулу того же гормона, в котором одна из гидроксильных групп заменена на что-то другое, например, атом хлора. Основным органом биотрансформации ЛС является печень. Как уже сказано, к стероидам относятся не только эфиры тестостерона, но и сходные с ним вещества. В печени различают реакции метаболизма I и II фазы. Заболевания печени. 4 — изменения метаболизма ЛС могут лежать в основе лекарственного взаимодействия, снижении терапевтической активности препаратов или повышения их токсичности. Некоторые лекарства действуют как индукторы ферментов, ответственных за метаболизм ксенобиотиков, и одновременно являются и субстратами ферментов, которые они активируют. Опасность от приема стероидов возникает не только во время длительного приема препаратов, но и при превышении допустимой нормы средства Конъюгация — филогенетически более древний путь метаболизма. При длительном применении препаратов, а также при резком прекращении приема мускулы могут «сдуться». Лекарственные средства (ЛС) относятся к факультативным гепатотоксинам. Сдувшиеся мышцы.
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