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Davison & Neale (2001) stated that during the mid nineteenth century Cannabis resin was utilized to treat rheumatism, gout, depression, cholera, and neuralgia, and from 1850-1942 marijuana was prescribed for rheumatism, nausea and labor pains.

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Substance abuses becomes a difficulty when a person who finds enjoyment using the difficulty knows may harmful whilst still having a continue to abuse the problem anyway.

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