Usuario:Sonuscomplete7

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It has been shown that hyperforin activates TRPC6 without affecting other TRPC channels, resulting in its antidepressant activity (Leuner et al., 2007). It also increases neurite outgrowth through MAPK, PI3K, and CaMK pathways in neuronal PC12 cells (Leuner et al., 2007; Heiser et al., 2013). Synthetic analogues of hyperforin, 2,4-diacylphloroglucinols, activated TRPC6 without affecting the closely related TRPC3 and TRPC7, and induced neurite outgrowth of PC12 cells (Leuner et al., 2010). In hippocampal neurons, hyperforin modulated dendritic spine morphology but had no effect on dendritic length and arborization (Leuner et al., 2013). These results suggest that TRPC6 but not TRPC3/TRPC7 induces neurotrophic effects triggered by hyperforin in neuronal cells. However, the activity of hyperforin via TRPC6 remains controversial; recent studies attribute the protonophore activity of hyperforin to its pharmacological effects (Tu et al., 2010; Sell et al., 2014). We recently reported piperazine-derived small activators for the DAG-sensitive TRPC channels TRPC3, TRPC6, and TRPC7, derived using chemical library screening. https://sonus-complete.info/