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Health-related quality of life effects of modafinil for treatment of narcolepsy. Objective: To determine if modafinil can improve fatigue in patients with post-polio syndrome. If you are currently on another treatment for narcolepsy, your doctor will advise you how best to withdraw from that treatment and begin taking MODAFINIL. Sleep disorders feature all these symptoms and are caused by numerous factors, including shift work disorders, narcolepsy, sleep apnea and others.
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The primary outcome measures were change in both the Epworth Sleepiness Scale and a modified Maintenance of Wakefulness Test, which were measured at the start of each arm of the trial and in week 3 of each intervention period. MFIS scores improved between day 0 and day 35 in both placebo-treated and modafinil-treated groups, but no significant difference was detected between the two groups. Twelve participants (2 female, 10 male) completed this study, consisting of 3 blocks of 7 sessions; each block tested a difference dose of modafinil. After adjusting for periods and order effects, no difference was observed between treatments.
